{"id":385,"date":"2025-05-20T00:00:20","date_gmt":"2025-05-20T00:00:20","guid":{"rendered":"https:\/\/wordpress-1197097-5471046.cloudwaysapps.com\/?p=385"},"modified":"2025-05-20T11:34:21","modified_gmt":"2025-05-20T11:34:21","slug":"advancing-drug-discovery-outcomes-with-virtual-cells-at-recursion","status":"publish","type":"post","link":"https:\/\/www.valencelabs.com\/fr\/advancing-drug-discovery-outcomes-with-virtual-cells-at-recursion\/","title":{"rendered":"Am\u00e9liorer les r\u00e9sultats de la d\u00e9couverte de m\u00e9dicaments gr\u00e2ce aux cellules virtuelles de Recursion"},"content":{"rendered":"<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Introduction<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">La qu\u00eate pour d\u00e9chiffrer la biologie est l\u2019un des d\u00e9fis les plus durables et les plus essentiels de l\u2019humanit\u00e9. La d\u00e9couverte traditionnelle de m\u00e9dicaments, un processus fastidieux qui s\u2019\u00e9tend souvent sur plus d\u2019une d\u00e9cennie et co\u00fbte des milliards, continue de subir un taux d\u2019\u00e9chec \u00e9lev\u00e9 en clinique. Nous pensons qu\u2019un changement fondamental est n\u00e9cessaire pour changer ce paradigme,  un changement qui conduit vers une compr\u00e9hension plus compl\u00e8te, pr\u00e9dictive et m\u00e9canistique de la biologie.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Et si nous pouvions construire des mod\u00e8les computationnels qui non seulement pr\u00e9disent les r\u00e9ponses cellulaires aux interventions, mais expliquent aussi <\/span><i><span style=\"font-weight: 400;\">pourquoi<\/span><\/i><span style=\"font-weight: 400;\"> ces r\u00e9ponses se produisent ? Et si ces \u00ab cellules virtuelles \u00bb pouvaient nous aider \u00e0 naviguer dans l\u2019immense complexit\u00e9 de la biologie pour d\u00e9couvrir et d\u00e9velopper de nouveaux m\u00e9dicaments de mani\u00e8re plus efficiente et efficace?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chez Valence Labs, le moteur de recherche en IA de Recursion, nous explorons cette fronti\u00e8re. Nous pensons que le moment est venu de concevoir les bases de ces cellules virtuelles. Dans notre article de perspective, \u201c<a href=\"https:\/\/www.valencelabs.com\/fr\/publications\/virtual-cells-predict-explain-discover\/\">Cellules virtuelles : Predict, Explain, Discover,<\/a>\u201d nous partageons notre r\u00e9flexion sur le d\u00e9veloppement et la validation de ces syst\u00e8mes.<\/span><\/p>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"wp-block-group blurred_container\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Pr\u00e9dire, expliquer, d\u00e9couvrir: les piliers de la cellule virtuelle<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Notre vision de la cellule virtuelle repose sur trois capacit\u00e9s interconnect\u00e9es:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pr\u00e9dire:<\/strong> Les cellules virtuelles doivent pr\u00e9dire avec pr\u00e9cision la fa\u00e7on dont les cellules r\u00e9pondent \u00e0 un large \u00e9ventail de perturbations \u2014 des modifications g\u00e9n\u00e9tiques aux nouveaux compos\u00e9s chimiques. La capacit\u00e9 \u00e0 pr\u00e9dire avec pr\u00e9cision les changements sur diverses lectures biologiques (expression des g\u00e8nes, activit\u00e9 des prot\u00e9ines, morphologie cellulaire) est essentielle pour hi\u00e9rarchiser les hypoth\u00e8ses et r\u00e9duire les risques dans les premi\u00e8res \u00e9tapes de la d\u00e9couverte de m\u00e9dicaments.<br><\/li>\n\n\n\n<li><strong>Expliquer:<\/strong> Allant au-del\u00e0 de la pr\u00e9diction, les cellules virtuelles doivent offrir des explications m\u00e9canistiques permettant de raisonner sur <em>ce qui se passerait sous diff\u00e9rentes interventions<\/em>, et pas seulement sur ce qui s\u2019est pass\u00e9. Cela implique d\u2019int\u00e9grer un raisonnement contrefactuel et de comprendre comment les perturbations se propagent \u00e0 travers l\u2019organisation complexe et hi\u00e9rarchique des syst\u00e8mes biologiques \u2014 des r\u00e9seaux mol\u00e9culaires aux fonctions cellulaires, en passant par les comportements au niveau des tissus, les syst\u00e8mes d'ordre sup\u00e9rieur et au-del\u00e0. De telles connaissances causales sont essentielles pour construire une compr\u00e9hension biologique et concevoir des interventions th\u00e9rapeutiques avec une pr\u00e9cision et une confiance accrues.<br><\/li>\n\n\n\n<li><strong>D\u00e9couvrir:<\/strong> Lorsque ces capacit\u00e9s pr\u00e9dictives et explicatives sont int\u00e9gr\u00e9es dans un cadre dynamique et ax\u00e9 sur l'apprentissage, les cellules virtuelles peuvent \u00e9voluer en de puissants moteurs de d\u00e9couverte biologique.. Nous envisageons des syst\u00e8mes qui g\u00e9n\u00e8rent de mani\u00e8re it\u00e9rative des hypoth\u00e8ses, con\u00e7oivent des exp\u00e9riences pour les valider et affinent continuellement leurs mod\u00e8les internes, guidant activement la recherche d\u2019opportunit\u00e9s th\u00e9rapeutiques.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"2196\" height=\"1470\" src=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1.png\" alt=\"\" class=\"wp-image-662\" srcset=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1.png 2196w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-300x201.png 300w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-1024x685.png 1024w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-768x514.png 768w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-1536x1028.png 1536w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-2048x1371.png 2048w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/12-1-18x12.png 18w\" sizes=\"auto, (max-width: 2196px) 100vw, 2196px\" \/><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Les piliers fondamentaux de Recursion permettent la poursuite de la cellule virtuelle<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">La r\u00e9alisation de cette vision est possible gr\u00e2ce aux capacit\u00e9s uniques de Recursion:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donn\u00e9es interventionnelles \u00e0 l\u2019\u00e9chelle industrielle:<\/b><span style=\"font-weight: 400;\"> La construction et la validation de cellules virtuelles n\u00e9cessitent des donn\u00e9es biologiques d'une ampleur et d'une diversit\u00e9 sans pr\u00e9c\u00e9dent. Recursion a consacr\u00e9 plus d\u2019une d\u00e9cennie \u00e0 la cr\u00e9ation de l\u2019un des ensembles de donn\u00e9es biologiques et chimiques propri\u00e9taires les plus importants et les plus pertinents au monde, d\u00e9passant d\u00e9sormais 65 p\u00e9taoctets. Ces donn\u00e9es dynamiques et interventionnelles couvrent la ph\u00e9nomique, <a href=\"https:\/\/www.recursion.com\/news\/computer-vision-based-digital-biomarkers-could-enable-faster-and-more-accurate-in-vivo-assessment-of-disease\" target=\"_blank\" rel=\"noopener\">l'invivomique<\/a>, <a href=\"https:\/\/ir.recursion.com\/news-releases\/news-release-details\/recursion-announces-data-collaboration-deal-tempus-top-50\" target=\"_blank\" rel=\"noopener\">les donn\u00e9es au niveau des patients<\/a> et bien plus encore. Avec jusqu'\u00e0 2,2 millions d'exp\u00e9riences ex\u00e9cut\u00e9es chaque semaine par les laboratoires automatis\u00e9s de Recursion <a href=\"https:\/\/www.recursion.com\/technology\" target=\"_blank\" rel=\"noopener\">automated labs<\/a>ces ensembles de donn\u00e9es continuent de s'\u00e9tendre.<\/span><span style=\"font-weight: 400;\"><br \/><br \/><\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>IA et apprentissage automatique pionniers pour la biologie:<\/b><span style=\"font-weight: 400;\"> Les techniques modernes d'IA\/ML alimentent les cellules virtuelles. Nous nous concentrons sur le d\u00e9veloppement et l'application d'approches de ML adapt\u00e9es \u00e0 la complexit\u00e9 de la biologie et de la d\u00e9couverte de m\u00e9dicaments, en nous appuyant sur une solide exp\u00e9rience qui comprend la <a href=\"https:\/\/www.valencelabs.com\/fr\/research\/\">recherche fondamentale<\/a>, <a href=\"https:\/\/ir.recursion.com\/news-releases\/news-release-details\/recursion-announces-release-openphenom-s16-google-clouds-model\" target=\"_blank\" rel=\"noopener\">les mod\u00e8les \u201copen source\u201d<\/a>et les <a href=\"https:\/\/polarishub.io\/\" target=\"_blank\" rel=\"noopener\">applications concr\u00e8tes.<\/a>.<\/span><span style=\"font-weight: 400;\"><br \/><br \/><\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Infrastructure sp\u00e9cialement con\u00e7ue de supercalcul:<\/b><span style=\"font-weight: 400;\"> L\u2019ampleur des donn\u00e9es biologiques et la complexit\u00e9 des mod\u00e8les d\u2019IA n\u00e9cessitent une capacit\u00e9 de calcul importante. <a href=\"https:\/\/ir.recursion.com\/news-releases\/news-release-details\/recursion-announces-completion-nvidia-powered-biohive-2-largest\" target=\"_blank\" rel=\"noopener\">BioHive-2<\/a>de Recursion, le superordinateur le plus puissant en biopharmaceutique, fournit l\u2019infrastructure essentielle pour entra\u00eener des mod\u00e8les de pointe et explorer les  fronti\u00e8res de la simulation biologique.<\/span><span style=\"font-weight: 400;\"><br \/><br \/><\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Synergie de l'automatisation et de l'IA:<\/b><span style=\"font-weight: 400;\"> L\u2019int\u00e9gration \u00e9troite entre l\u2019automatisation avanc\u00e9e des laboratoires de Recursion et le d\u00e9veloppement de mod\u00e8les d\u2019IA de Valence Labs cr\u00e9e cr\u00e9e de puissantes boucles de r\u00e9troaction, permettant des cycles rapides de g\u00e9n\u00e9ration d'hypoth\u00e8ses, de validation exp\u00e9rimentale et d'affinement des mod\u00e8les.<\/span><\/li>\n<\/ul>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Pr\u00e9parer le terrain : TxPert comme premi\u00e8re \u00e9tape de notre plan directeur<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">Avec Recursion, nous prenons des mesures concr\u00e8tes et it\u00e9ratives pour renforcer nos fondations sur la voie des  cellules virtuelles. Aujourd'hui, parall\u00e8lement \u00e0 notre article de perspective, nous pr\u00e9sentons TxPert, un mod\u00e8le de pointe capable de pr\u00e9dire les r\u00e9ponses transcriptionnelles \u00e0 des perturbations g\u00e9n\u00e9tiques combinatoires. Con\u00e7u pour \u00eatre robuste dans des sc\u00e9narios hors distribution, il pr\u00e9dit les effets de knockdowns g\u00e9n\u00e9tiques in\u00e9dits, de combinaisons de perturbations ou de r\u00e9ponses dans de nouveaux contextes cellulaires.<br \/><br \/><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-441 size-full\" src=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task.webp\" alt=\"\" width=\"1360\" height=\"1360\" srcset=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task.webp 1360w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task-300x300.webp 300w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task-1024x1024.webp 1024w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task-150x150.webp 150w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task-768x768.webp 768w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/architecture_and_task-12x12.webp 12w\" sizes=\"auto, (max-width: 1360px) 100vw, 1360px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Pr\u00e9dire avec pr\u00e9cision ces r\u00e9ponses est essentiel pour hi\u00e9rarchiser les hypoth\u00e8ses en d\u00e9couverte de m\u00e9dicaments, o\u00f9 les tests exp\u00e9rimentaux de toutes les possibilit\u00e9s ne sont ni scalable ni \u00e9conomiques. TxPert atteint des performances \u00e9lev\u00e9es en exploitant lesr\u00e9seaux de connaissances biologiques et des architectures bas\u00e9es sur les graphes pour capturer des effets sp\u00e9cifiques au contexte et g\u00e9n\u00e9raliser au-del\u00e0 des donn\u00e9es d\u2019entra\u00eenement.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-440 size-full\" src=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17.webp\" alt=\"\" width=\"1784\" height=\"1362\" srcset=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17.webp 1784w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17-300x229.webp 300w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17-1024x782.webp 1024w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17-768x586.webp 768w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17-1536x1173.webp 1536w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/infographic_17-16x12.webp 16w\" sizes=\"auto, (max-width: 1784px) 100vw, 1784px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">TxPert aborde la capacit\u00e9 de \u201c<\/span><b>Pr\u00e9diction<\/b><span style=\"font-weight: 400;\">\u201d de notre cadre de travail. Il repr\u00e9sente une premi\u00e8re \u00e9tape dans notre voyage vers la cellule virtuelle, et le cadre d\u2019analyse comparative qu\u2019il introduit illustre notre engagement \u00e0 construire des mod\u00e8les \u00e9clair\u00e9s par la complexit\u00e9 biologique et guid\u00e9s par les r\u00e9sultats r\u00e9els de la d\u00e9couverte de m\u00e9dicaments.<\/span><\/p>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Le moteur de la d\u00e9couverte: des syst\u00e8mes agentiques<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">La cellule virtuelle est un syst\u00e8me dynamique en perp\u00e9tuel apprentissage. Comme d\u00e9taill\u00e9 dans notre article, nous envisageons un paradigme du \u00ab laboratoire dans la boucle \u00bb o\u00f9 les cellules virtuelles sont affin\u00e9es de mani\u00e8re it\u00e9rative. Conceptuellement, une cellule virtuelle peut \u00eatre consid\u00e9r\u00e9e comme une th\u00e9orie de la physiologie et de la pathologie cellulaires humaines qui g\u00e9n\u00e8re des hypoth\u00e8ses sur les syst\u00e8mes biologiques, observables \u00e0 travers des exp\u00e9riences.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Les agents peuvent ensuite utiliser ces hypoth\u00e8ses pour concevoir et ex\u00e9cuter des exp\u00e9riences en laboratoire, cherchant explicitement \u00e0 falsifier la \u00ab th\u00e9orie \u00bb actuelle de la cellule virtuelle. Une exp\u00e9rience qui prouve qu'une pr\u00e9diction est erron\u00e9e devient une opportunit\u00e9 d'apprentissage cruciale. Cela permet d\u2019affiner le mod\u00e8le, le rendant plus pr\u00e9cis et plus robuste. En recherchant activement des exp\u00e9riences qui falsifient la cellule virtuelle actuelle, nous pouvons d\u00e9couvrir une nouvelle biologie et acc\u00e9l\u00e9rer la d\u00e9couverte th\u00e9rapeutique.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ce cycle \u2013 pr\u00e9dire, tester (falsifier), affiner \u2013 cr\u00e9e un puissant moteur de d\u00e9couverte. Dans le contexte de la d\u00e9couverte de m\u00e9dicaments, cela repr\u00e9sente un passage du paradigme plus lent \u00abconcevoir-fabriquer-tester-mesurer\u00bb \u00e0 une approche plus rapide \u00abconcevoir-simuler-tester-apprendre\u00bb ou \u00abconcevoir-simuler\u00bb, ouvrant la voie \u00e0 de nouvelles opportunit\u00e9s th\u00e9rapeutiques.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">L\u2019exploration de la mani\u00e8re dont les syst\u00e8mes agentiques peuvent acc\u00e9l\u00e9rer ce cycle est un objectif cl\u00e9. Nous d\u00e9veloppons activement des syst\u00e8mes capables non seulement de g\u00e9n\u00e9rer conditionnellement des hypoth\u00e8ses \u00e0 l'aide de cellules virtuelles, mais \u00e9galement de prioriser les hypoth\u00e8ses \u00e0 falsifier, de concevoir des exp\u00e9riences pour tester efficacement ces hypoth\u00e8ses, d'orchestrer l'ex\u00e9cution des exp\u00e9riences, d'analyser les r\u00e9sultats exp\u00e9rimentaux et de les int\u00e9grer dans la cellule virtuelle pour un raffinement it\u00e9ratif. Les travaux de Recursion sur le moteur de flux de travail orchestr\u00e9 (LOWE [LLM orchestrated workflow engine]) illustrent ce potentiel.<a href=\"https:\/\/www.recursion.com\/lowe\" target=\"_blank\" rel=\"noopener\">LOWE<\/a>) illustrates this potential.<br \/><\/span><\/p>\n<p>\u00a0<\/p>\n<p><iframe loading=\"lazy\" style=\"width: 100%; min-height: 380px;\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/2phoSofu5SI?si=vk0G82gM77KE8Btf\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\"><\/span><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\"><\/span><\/iframe><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Relier les \u00e9chelles biologiques: Des m\u00e9canismes mol\u00e9culaires \u00e0 la fonction cellulaire<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">Une cellule virtuelle doit \u00e9galement combler le foss\u00e9 entre le monde mol\u00e9culaire et les ph\u00e9nom\u00e8nes cellulaires. Bien que la simulation de cellules enti\u00e8res \u00e0 partir des premiers principes ne soit pas encore r\u00e9alisable, nous visons une int\u00e9gration \u00e0 toutes les \u00e9chelles. Cela implique de tirer parti de simulations ascendantes de haute fid\u00e9lit\u00e9 pour les \u00e9v\u00e9nements mol\u00e9culaires cl\u00e9s, et de connecter ces mod\u00e8les bas\u00e9s sur la physique avec des donn\u00e9es fonctionnelles issues des exp\u00e9riences cellulaires \u00e0 grande \u00e9chelle de Recursion. <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Nos recherches comprennent l'exploration de techniques avanc\u00e9es de mod\u00e9lisation mol\u00e9culaire, y compris des domaines li\u00e9s \u00e0 la compr\u00e9hension des propri\u00e9t\u00e9s chimiques d\u00e9riv\u00e9es du quantique (c'est-\u00e0-dire OpenQDC), afin d'insuffler \u00e0 nos mod\u00e8les avec une compr\u00e9hension m\u00e9caniste plus approfondie.<\/span><\/p>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"fifty_fifty\">\n    <div class=\"container\">\n        <div class=\"left__col\">\n            <h2>Une voie \u00e0 suivre: Analyse rigoureuse et progr\u00e8s collaboratifs<\/h2>\n                    <\/div>\n        <div class=\"right__col\">\n            <div class=\"desc\">\n                <p><span style=\"font-weight: 400;\">Des progr\u00e8s tangibles dans le d\u00e9veloppement de cellules virtuelles d\u00e9pendent de l\u2019\u00e9tablissement et de l\u2019adoption de crit\u00e8res de r\u00e9f\u00e9rence robustes et fond\u00e9s sur la biologie. L\u2019\u00e9valuation standardis\u00e9e est essentielle pour garantir que les nouvelles m\u00e9thodes am\u00e9liorent les capacit\u00e9s pr\u00e9dictives et explicatives.<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Les initiatives favorisant des plateformes d\u2019\u00e9valuation ouvertes, comme <\/span><a href=\"https:\/\/polarishub.io\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Polaris<\/span><\/a><span style=\"font-weight: 400;\">, et le partage de jeux de donn\u00e9es de haute qualit\u00e9, tels que <\/span><a href=\"https:\/\/www.rxrx.ai\/rxrx3-core\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">RxRx3-core<\/span><\/a><span style=\"font-weight: 400;\">, sont des \u00e9tapes cruciales pour \u00e9tablir ces normes \u00e9lev\u00e9es et encourager des avanc\u00e9es transparentes dans tout le domaine. <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Notre objectif ultime est de contribuer \u00e0 un avenir o\u00f9 la d\u00e9couverte de m\u00e9dicaments est consid\u00e9rablement acc\u00e9l\u00e9r\u00e9e et o\u00f9 la probabilit\u00e9 de succ\u00e8s sera consid\u00e9rablement acc\u00e9l\u00e9r\u00e9e et o\u00f9 la probabilit\u00e9 de succ\u00e8s est consid\u00e9rablement augment\u00e9e pour les th\u00e9rapies r\u00e9pondant aux besoins critiques des patients. La voie vers les cellules virtuelles et, \u00e0 terme, les tissus virtuels, les organes et m\u00eame les mod\u00e8les sp\u00e9cifiques aux patients est ambitieuse, mais elle ouvre la voie vers une nouvelle \u00e8re de m\u00e9decine de pr\u00e9cision.<br \/><br \/><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-629 size-full\" src=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-scaled.png\" alt=\"\" width=\"2560\" height=\"1600\" srcset=\"https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-scaled.png 2560w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-300x187.png 300w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-1024x640.png 1024w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-768x480.png 768w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-1536x960.png 1536w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-2048x1280.png 2048w, https:\/\/www.valencelabs.com\/wp-content\/uploads\/2025\/05\/4-2-18x12.png 18w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><br \/><br \/><\/p>\n<p><span style=\"font-weight: 400;\">Nous sommes enthousiastes de partager notre perspective et nos travaux en cours, et nous invitons l\u2019ensemble de la communaut\u00e9 scientifique \u00e0 s\u2019engager avec ces id\u00e9es, \u00e0 les remettre en question et \u00e0 s'en inspirer alors que nous travaillons collectivement vers un nouveau paradigme plus pr\u00e9visible et plus puissant dans la d\u00e9couverte de nouveaux m\u00e9dicaments.<\/span><\/p>\n<p><b>Nous vous encourageons \u00e0 lire l'int\u00e9gralit\u00e9 de notre article de perspective, \u201c<a href=\"https:\/\/www.valencelabs.com\/fr\/publications\/virtual-cells-predict-explain-discover\/\">Cellules virtuelles : Predict, Explain, Discover,<\/a>\u201d pour approfondir la vision qui guide nos recherches chez Valence Labs.<\/b><\/p>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Predict, Explain, Discover: The Pillars of the Virtual Cell Our view of the virtual cell rests on three interconnected capabilities:<\/p>","protected":false},"author":3,"featured_media":620,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[3],"class_list":["post-385","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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